tyrosine Kinase, Non-Receptor, 2 (TNK2) (C-Term) Peptide

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Protein Name
  • ACK
  • ACK-1
  • ACK1
  • p21cdc42Hs
  • AW552477
  • Ack
  • Cdgip
  • Pyk1
  • tyrosine kinase, non-receptor, 2
  • TNK2
  • Tnk2
  • LOC100350340
Protein Region
Peptide Type
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP7696b was selected from the C-term region of human ACK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Yokoyama, Miller: "Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47713-23, 2003 (PubMed).

Manser, Leung, Salihuddin, Tan, Lim: "A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42." in: Nature, Vol. 363, Issue 6427, pp. 364-7, 1993 (PubMed).