Activin Receptor Type I (ACRV1) (Center), (Arg147) Peptide

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Protein Name
  • ALK2
  • ActR-I
  • ActRIA
  • Acvr
  • Acvrlk2
  • Alk-2
  • Alk8
  • D330013D15Rik
  • SKR1
  • Tsk7L
  • ACTRI
  • ACVR1A
  • ACVRLK2
  • FOP
  • TSRI
  • ActR-IA
  • activin A receptor, type 1
  • activin A receptor, type I
  • Acvr1
  • ACVR1
Protein Region
Center, Arg147
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP7806c was selected from the Center region of human ACVR1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." in: Oncogene, Vol. 8, Issue 10, pp. 2879-87, 1993 (PubMed).

Matsuzaki, Xu, Wang, McKeehan, Krummen, Kan: "A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12719-23, 1993 (PubMed).