AAK1 (N-Term) Peptide
| Catalog no. |
ABIN697681 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for AAK1 (N-term) antibody ABIN652404
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Specificity
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The synthetic peptide sequence used to generate the antibody AP7861a was selected from the N-term region of human AAK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Takahashi, Furuchi, Naganuma: "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells." in: Cancer research, Vol. 66, Issue 24, pp. 11932-7, 2006 (PubMed).
Henderson, Conner: "A novel AAK1 splice variant functions at multiple steps of the endocytic pathway." in: Molecular biology of the cell, Vol. 18, Issue 7, pp. 2698-706, 2007 (PubMed).
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Alternatives for antigen "AAK1", type "Peptides"
2013 BioMed Central Research Awards
