tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, zeta Polypeptide (YWHAZ) (Thr232) Peptide

Details for Product No. ABIN698020
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Protein Name
Synonyms
14-3-3, 14-3-3 zeta, 14-3-3-zeta, 14-3-3ZETA, 14-3-3leo, 2G1, 4-3-3 zeta, 5.11, 549, BEST:GH05075, CG17870, D14-3-3, D14-3-3zeta, Dmel\\CG17870, K, LEO, Leo, PAR-5, PAR5, Par-5, d14-3-3zeta, l(2)07103 ... show more
14-3-3, 14-3-3 zeta, 14-3-3-zeta, 14-3-3ZETA, 14-3-3leo, 2G1, 4-3-3 zeta, 5.11, 549, BEST:GH05075, CG17870, D14-3-3, D14-3-3zeta, Dmel\\CG17870, K, LEO, Leo, PAR-5, PAR5, Par-5, d14-3-3zeta, l(2)07103, l(2)46CFe, l(2)46Ee, leo, par-5, 14-3-3z, 14-3-3zeta, kcip-1, ywhaq, ACYPI003154, 1433z, Ywhaz, 14-3-3-zetaisoform, Pkcz, r14-3-3, 1300003C17Rik, KCIP-1, YWHAD, 1110013I11Rik, AI596267, AL022924, AU020854, ywhaz, ywhaza, fb14h09, wu:fb05g08, wu:fb14h09, ywhai, zgc:55807, ywhazb show less
Protein Region
Thr232
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN698020
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP8152d was selected from the T232 region of human 14-3-3 protein zeta/delta. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name 14-3-3 protein zeta/delta
Background 14-3-3 protein zeta/delta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Li, Zhao, Du et al.: "Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 162-7, 2008 (PubMed).

Li, Mofunanya, Harris et al.: "Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity." in: The Journal of cell biology, Vol. 181, Issue 7, pp. 1141-54, 2008 (PubMed).

Validation Images
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