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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, zeta Polypeptide (YWHAZ) (Thr232) Peptide

Details for Product No. ABIN698020, Supplier: Log in to see
Protein Name
  • 14-3-3
  • 14-3-3 zeta
  • 14-3-3-zeta
  • 14-3-3ZETA
  • 14-3-3leo
  • 2G1
  • 4-3-3 zeta
  • 5.11
  • 549
  • BEST:GH05075
  • CG17870
  • D14-3-3
  • D14-3-3zeta
  • Dmel\\CG17870
  • K
  • LEO
  • Leo
  • PAR-5
  • PAR5
  • Par-5
  • d14-3-3zeta
  • l(2)07103
  • l(2)46CFe
  • l(2)46Ee
  • leo
  • par-5
  • 14-3-3z
  • 14-3-3zeta
  • kcip-1
  • ywhaq
  • ACYPI003154
  • 1433z
  • Ywhaz
  • 14-3-3-zetaisoform
  • Pkcz
  • r14-3-3
  • 1300003C17Rik
  • KCIP-1
  • YWHAD
  • 1110013I11Rik
  • AI596267
  • AL022924
  • AU020854
  • ywhaz
  • ywhaza
  • fb14h09
  • wu:fb05g08
  • wu:fb14h09
  • ywhai
  • zgc:55807
  • ywhazb
Protein Region
Thr232
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP8152d was selected from the T232 region of human 14-3-3 protein zeta/delta. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background 14-3-3 protein zeta/delta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Li, Mofunanya, Harris et al.: "Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity." in: The Journal of cell biology, Vol. 181, Issue 7, pp. 1141-54, 2008 (PubMed).

Li, Zhao, Du et al.: "Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 162-7, 2008 (PubMed).