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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (C-Term) Peptide

Details for Product No. ABIN698025
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Protein Name
Synonyms hs1, gw128, kcip-1, 14-3-3beta, 1433b, YWHAB, DKFZp459L1720, GW128, HS1, KCIP-1, YWHAA, 1300003C17Rik
Protein Region
C-Term
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN698025
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP8155b was selected from the 14-3-3 region of human YWHAB (14-3-3 protein beta/alpha) . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name YWHAB (14-3-3 protein beta/alpha)
Background YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Shumway, Li, Xiong: "14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2089-92, 2003 (PubMed).

Parvaresch, Yesilkaya, Baer et al.: "14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation." in: FEBS letters, Vol. 532, Issue 3, pp. 357-62, 2002 (PubMed).

Li, Inoki, Vacratsis et al.: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, 2003 (PubMed).

Cavet, Lehoux, Berk: "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18376-83, 2003 (PubMed).

Komori, Ishizawa, Arai et al.: "Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy." in: Acta neuropathologica, Vol. 106, Issue 1, pp. 66-70, 2003 (PubMed).

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