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Details for Product No. ABIN698159

phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (Center) Peptide

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Protein Name
Synonyms Pla2c, cPLA2, Pla2g4, PLA2, PLA2G1B, CPLA2, PLA2G4, PLA2G4A, cPLA2alpha, cPLA2-alpha, pla2g4
Protein Region
Center
Application
Blocking Peptide (BP)
Pubmed 2 references available
Catalog no. ABIN698159
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP8510c was selected from the Center region of human PLA2G4A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name PLA2G4A
Background PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Comment

Background: PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Sharp, White, Chiou et al.: "Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 14850-3, 1991 (PubMed).

Clark, Lin, Kriz et al.: "A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP." in: Cell, Vol. 65, Issue 6, pp. 1043-51, 1991 (PubMed).

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