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phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (Center) Peptide

Details for Product No. ABIN698159, Supplier: Log in to see
Protein Name
  • CPLA2
  • cPLA2
  • cPLA2-alpha
  • cPLA2alpha
  • PLA2
  • Pla2c
  • PLA2G1B
  • PLA2G4
  • Pla2g4
  • pla2g4
  • PLA2G4A
Protein Region
Center
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP8510c was selected from the Center region of human PLA2G4A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Sharp, White, Chiou, Goodson, Gamboa, McClure, Burgett, Hoskins, Skatrud, Sportsman: "Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 14850-3, 1991 (PubMed).

Clark, Lin, Kriz, Ramesha, Sultzman, Lin, Milona, Knopf: "A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP." in: Cell, Vol. 65, Issue 6, pp. 1043-51, 1991 (PubMed).