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Chromobox Homolog 1 (CBX1) (C-Term) Peptide

Details for Product No. ABIN698535, Supplier: Log in to see
Protein Name
  • Cbx
  • Cbx-rs2
  • E430007M08Rik
  • HP1B
  • Hp1beta
  • M31
  • MOD1
  • CBX
  • HP1-BETA
  • HP1Hs-beta
  • HP1Hsbeta
  • p25beta
  • cbx1
  • wu:fe14b09
  • zgc:55739
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP8915c was selected from the C-term region of human CBX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background CBX1 is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Aagaard, Laible, Selenko et al.: "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31." in: The EMBO journal, Vol. 18, Issue 7, pp. 1923-38, 1999 (PubMed).