Chromobox Homolog 1 (CBX1) (C-Term) Peptide
| Name | Chromobox Homolog 1 (CBX1) |
| Synonyms | CBX, M31, MOD1, p25beta, HP1-BETA, HP1Hsbeta, HP1Hs-beta |
| Binding Site |
C-Term |
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1 reference available |
| Certificates | ISO 9001:2008 |
| Catalog no. | ABIN698535 |
| Quantity | 0.1 mg |
| Price | 49.50 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 2 to 3 Business Days |
Additional Information
| Immunogen | Synthetic peptide |
| Characteristics | Blocking peptide for CBX1 (C-term) antibody ABIN652861 |
| Specificity | The synthetic peptide sequence used to generate the antibody AP8915c was selected from the C-term region of human CBX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Comments |
Background: CBX1 is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. |
Application Details
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles |
| Restrictions | For Research Use only |
Publications
| Product |
Aagaard, Laible, Selenko et al.: "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31." in: The EMBO journal, Vol. 18, Issue 7, pp. 1923-38, 1999 (PubMed).
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Sponsorship
2013 BioMed Central Research Awards
2013 BioMed Central Research Awards
