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Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (C-Term) Peptide

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Protein Name
Synonyms cp2b, cyp1, cyp1alpha, cyp27b, p450c1, pddr, vdd1, vddr, vddri, vdr, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, Cyp40, Cp2b, Cyp1, Cyp27b, Pddr, Vdd1, Vddr, VddrI, Vdr
Protein Region
C-Term
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 1 reference available
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Quantity 0.1 mg
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Specificity The synthetic peptide sequence used to generate the antibody AP9056b was selected from the C-term region of human CYP27B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Simon, Munger, Xing Yang et al.: "Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 2, pp. 133-8, 2010 (PubMed).

Catalog No. ABIN698662
$88.00
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