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Details for Product No. ABIN698877

Xanthine Dehydrogenase (XDH) (N-Term) Peptide

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Protein Name
Synonyms XO, XOR, Xor, Xox1, Xox-1, XDH, im:7146167, DDBDRAFT_0219626, DDBDRAFT_0230176, DDB_0219626, DDB_0230176
Protein Region
N-Term
Application
Blocking Peptide (BP)
Pubmed 2 references available
Catalog no. ABIN698877
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity The synthetic peptide sequence used to generate the antibody AP9277a was selected from the N-term region of human XDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name XDH
Background XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Comment

Background: XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Taibi, Carruba, Miceli et al.: "Estradiol decreases xanthine dehydrogenase enzyme activity and protein expression in non-tumorigenic and malignant human mammary epithelial cells." in: Journal of cellular biochemistry, Vol. 108, Issue 3, pp. 688-92, 2009 (PubMed).

Ross, Katzov-Eckert, Dubé et al.: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, 2009 (PubMed).

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