Did you know that you can buy products from over 140 different suppliers from us?

TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Center) Peptide

Details for Product No. ABIN698979
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Protein Name
Synonyms 3'-Tab1, MAP3K7IP1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Protein Region
Center
Application
Blocking Peptide (BP)
Pubmed 3 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN698979
49.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Alternative Name TAB1
Background TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Neil, Schiemann: "Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression." in: Cancer research, Vol. 68, Issue 5, pp. 1462-70, 2008 (PubMed).

Prickett, Ninomiya-Tsuji, Broglie et al.: "TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19245-54, 2008 (PubMed).

Isono, Kim, Ando et al.: "Suppression of cell invasiveness by periostin via TAB1/TAK1." in: International journal of oncology, Vol. 35, Issue 2, pp. 425-32, 2009 (PubMed).

Validation Images
back to top