Hepcidin Antimicrobial Peptide (HAMP) (Center) Peptide

Details for Product No. ABIN699058
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Protein Name
Synonyms HEPC, HFE2B, LEAP1, PLTR, Hepc, Hamp1, Hepc1, hepcidin, Hepcidin, HAMP
Protein Region
Center
Application
Blocking Peptide (BP)
Pubmed 1 reference available
Catalog no. ABIN699058
Quantity 0.1 mg
Price
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Alternative Name HAMP
Background HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
Comment

Background: HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Hunter, Fulton, Ganz et al.: "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37597-603, 2002 (PubMed).

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