NAL11 (Center) Peptide

Details for Product No. ABIN699565, Supplier: Log in to see
Protein Name
Protein Region
Blocking Peptide (BP)
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Background NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Baranzini, Wang, Gibson, Galwey, Naegelin, Barkhof, Radue, Lindberg, Uitdehaag, Johnson, Angelakopoulou, Hall, Richardson, Prinjha, Gass, Geurts, Kragt, Sombekke, Vrenken, Qualley, Lincoln et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis...." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Enjuanes, Benavente, Bosch, Martín-Guerrero, Colomer, Pérez-Alvarez, Reina, Ardanaz, Jares, García-Orad, Pujana, Montserrat, de Sanjosé, Campo: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Dowds, Masumoto, Chen, Ogura, Inohara, Núñez: "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product." in: Biochemical and biophysical research communications, Vol. 302, Issue 3, pp. 575-80, 2003 (PubMed).