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NAL11 (Center) Peptide

Name

NAL11
Binding Site

Center
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN699565
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Characteristics Blocking peptide for NAL11 (Center) antibody ABIN653949
Comments

Background: NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Dowds, Masumoto, Chen et al.: "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product." in: Biochemical and biophysical research communications, Vol. 302, Issue 3, pp. 575-80, 2003 (PubMed).

Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).