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Details for Product No. ABIN699718

Napsin A Aspartic Peptidase (NAPSA) (C-Term) Peptide

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Protein Name
Synonyms KAP, Kdap, NAP1, NAPA, SNAPA, pronapsin
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 3 references available
Catalog no. ABIN699718
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13772b was selected from the C-term region of NAPSA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name NAPSA
Background The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq].
Comment

Background: The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq].

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Brasch, Ochs, Kahne et al.: "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung." in: The Journal of biological chemistry, Vol. 278, Issue 49, pp. 49006-14, 2003 (PubMed).

Innocenti, Zucconi, Disanza et al.: "Abi1 is essential for the formation and activation of a WAVE2 signalling complex." in: Nature cell biology, Vol. 6, Issue 4, pp. 319-27, 2004 (PubMed).

Bishop, Sharma, Illei: "Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma." in: Human pathology, Vol. 41, Issue 1, pp. 20-5, 2009 (PubMed).

Alternatives for antigen "Napsin A Aspartic Peptidase (NAPSA)", type "Peptides"
Reactivities (2)
Beacon