Amiloride Binding Protein 1 (Amine Oxidase (Copper-Containing)) (ABP1) (N-Term) Peptide

Details for Product No. ABIN699728
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Protein Name
Protein Region
N-Term
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 4 references available
Quantity 0.1 mg
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13940a was selected from the N-term region of ABP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name ABP1
Background This gene encodes a membrane glycoprotein that is expressed in many epithelium-rich and/or hematopoietic tissues and oxidatively deaminates putrescine and histamine. The protein may play a role in controlling the level of histamine and/or putrescine in these tissues. It also binds to and is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

McGrath, Hilmer, Collyer et al.: "A new crystal form of human diamine oxidase." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 66, Issue Pt 2, pp. 137-42, 2010 (PubMed).

McGrath, Hilmer, Collyer et al.: "Structure and inhibition of human diamine oxidase." in: Biochemistry, Vol. 48, Issue 41, pp. 9810-22, 2009 (PubMed).

Song, Lv, Zhang et al.: "Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease." in: World journal of gastroenterology : WJG, Vol. 15, Issue 31, pp. 3916-9, 2009 (PubMed).

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Catalog No. ABIN699728
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