Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr179) Peptide

Details for Product No. ABIN699945
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Protein Name
Synonyms
P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csb ... show more
P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csbp, mapk14a, mxi2, sapk2, sapk2a, p38b, zp38b, MAPK14, 186F5S, BG:DS00797.3, CG7393, D-p38, D-p38 MAPK, D-p38b, Dm p38b, Dmel\\CG7393, Dmp38b, Dp38, Dp38b, ESTS:186F5S, Mpk34C, anon-sts23, dp38b, p38 MAPK, p38 beta, p38B, p38Kb, p38beta show less
Protein Region
pThr179
Application
Blocking Peptide (BP)
Pubmed 2 references available
Catalog no. ABIN699945
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP3422a was selected from the region of human Phospho-MAPK14-pT179. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name MAPK14
Background MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Comment

Background: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dean, Sarsfield, Tsounakou et al.: "p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39470-6, 2003 (PubMed).

Cheung, Campbell, Nebreda et al.: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003 (PubMed).

back to top