|+1 404 474 4654|
|+1 888 205 9894 (TF)|
zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (Center) Peptide
|Synonyms||SRK, STD, TZK, ZAP-70, FLJ17670, FLJ17679, Srk, mur, 70kDa, mrtle, AI327364, MGC108902, zap70, MGC80670, MGC88962, ZAP70|
|5 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for ZAP70 (Center) antibody ABIN392281|
|Specificity||The synthetic peptide sequence used to generate the antibody AP7824c was selected from the Center region of human ZAP70 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Wiestner, Rosenwald, Barry et al.: "ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile." in: Blood, Vol. 101, Issue 12, pp. 4944-51, 2003 (PubMed).
Kremer, Humphreys, Kumar et al.: "Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 1, pp. 360-7, 2003 (PubMed).
Kuhné, Lin, Yablonski et al.: "Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 860-6, 2003 (PubMed).
Yang, Villain, Mustelin et al.: "Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells." in: Molecular and cellular biology, Vol. 23, Issue 21, pp. 7667-77, 2003 (PubMed).
Kuroyama, Ikeda, Kasai et al.: "Identification of a novel isoform of ZAP-70, truncated ZAP kinase." in: Biochemical and biophysical research communications, Vol. 315, Issue 4, pp. 935-41, 2004 (PubMed).