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zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (Center) Peptide

Name

zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70)
Synonyms SRK, STD, TZK, ZAP-70, FLJ17670, FLJ17679, Srk, mur, 70kDa, mrtle, AI327364, MGC108902, zap70, MGC80670, MGC88962, ZAP70
Binding Site

Center
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN700197
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for ZAP70 (Center) antibody ABIN392281
Specificity The synthetic peptide sequence used to generate the antibody AP7824c was selected from the Center region of human ZAP70 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Wiestner, Rosenwald, Barry et al.: "ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile." in: Blood, Vol. 101, Issue 12, pp. 4944-51, 2003 (PubMed).

Kremer, Humphreys, Kumar et al.: "Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 1, pp. 360-7, 2003 (PubMed).

Kuhné, Lin, Yablonski et al.: "Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 860-6, 2003 (PubMed).

Yang, Villain, Mustelin et al.: "Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells." in: Molecular and cellular biology, Vol. 23, Issue 21, pp. 7667-77, 2003 (PubMed).

Kuroyama, Ikeda, Kasai et al.: "Identification of a novel isoform of ZAP-70, truncated ZAP kinase." in: Biochemical and biophysical research communications, Vol. 315, Issue 4, pp. 935-41, 2004 (PubMed).

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Alternatives for antigen "zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70)", type "Peptides"
Reactivities Human (10), Mouse (Murine) (9), Rat (Rattus) (4)