Phosphodiesterase 12 (PDE12) (Middle Region) Peptide
PDE12
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PDE12 products
- PDE12 (Phosphodiesterase 12 (PDE12))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-2'-PDE antibody (Catalog #: ARP53350_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PDE12 (Phosphodiesterase 12 (PDE12))
- Synonyms
- 2'-PDE Peptide, E430028B21Rik Peptide, LRRGT00074 Peptide, RGD1310975 Peptide, phosphodiesterase 12 S homeolog Peptide, phosphodiesterase 12 Peptide, pde12.S Peptide, PDE12 Peptide, pde12 Peptide, Pde12 Peptide
- Background
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2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Alias Symbols: 2'-PDE
Protein Interaction Partner: UBL4A
Protein Size: 609 - Molecular Weight
- 67 kDa
- Gene ID
- 201626
- NCBI Accession
- NM_177966, NP_808881
- UniProt
- Q6L8Q7
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