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Autoimmune Regulator (AIRE) Peptide

AIRE Reactivity: Human Host: Synthetic BP, WB, IHC
Catalog No. ABIN973041
  • Target See all AIRE products
    AIRE (Autoimmune Regulator (AIRE))
    Origin
    Human
    Source
    • 10
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-AIRE antibody (Catalog #: ARP32650_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    AIRE (Autoimmune Regulator (AIRE))
    Synonyms
    AIRE1 Peptide, APECED Peptide, APS1 Peptide, APSI Peptide, PGA1 Peptide, autoimmune regulator Peptide, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Peptide, AaeL_AAEL013794 Peptide, CpipJ_CPIJ001208 Peptide, CpipJ_CPIJ001209 Peptide, AIRE Peptide, Aire Peptide
    Background
    The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

    Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1

    Protein Interaction Partner: AIRE,CREBBP,AIRE,CREBBP,AIRE,CHD6,CREBBP,DDX17,DDX5,EFTUD2,GEMIN5,HIST1H2AC,HIST1H2BO,IPO7,KPNB1,LMNB1,MCM2,MCM5,MCM6,MSH2,MSH6,MYBBP1A,NASP,NOP56,NUP93,PABPC1,PARP1,PCNA,POLR2A,POLR2B,PRKDC,RAD21,RANBP2,RANBP9,RUVBL2,SMC1A,SMC3,SNRPB,SNRPD3,SRSF1,SRSF2,SRSF3,SSRP1,TOP2A,TRIM28,XPO1,XPOT

    Protein Size: 545
    Molecular Weight
    58 kDa
    Gene ID
    326
    NCBI Accession
    NM_000383, NP_000374
    UniProt
    O43918
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