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Beta-secretase 1 (BACE1) (N-Term) Peptide

BACE1 Reactivity: Human Host: Synthetic BP, WB, IHC
Catalog No. ABIN973702
  • Target See all BACE1 products
    BACE1 (Beta-secretase 1 (BACE1))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-BACE1 antibody (Catalog #: ARP46851_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    BACE1 (Beta-secretase 1 (BACE1))
    Synonyms
    ASP2 Peptide, BACE Peptide, HSPC104 Peptide, C76936 Peptide, Bace Peptide, MGC145931 Peptide, BACE1 Peptide, zgc:77409 Peptide, beta-secretase 1 Peptide, beta-site APP cleaving enzyme 1 Peptide, beta-site APP-cleaving enzyme 1 Peptide, BACE1 Peptide, Bace1 Peptide, bace1 Peptide
    Background
    Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein. BACE1, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.

    Alias Symbols: ASP2, BACE, FLJ90568, HSPC104, KIAA1149

    Protein Interaction Partner: ATP1B1,CMPK1,ITM2C,KHSRP,NCSTN,PDIA3,PSAP,RANBP9,APP,ATP1B1,BRI3,CMPK1,CSNK1D,FURIN,GGA2,ITM2C,KHSRP,LRP1,MMP2,NCSTN,PDIA3,PLSCR1,PSAP,PSEN1,RANBP9,SELPLG,NCSTN

    Protein Size: 501
    Molecular Weight
    51 kDa
    Gene ID
    23621
    NCBI Accession
    NM_012104, NP_036236
    UniProt
    P56817
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