Breast Cancer 1 (BRCA1) (Middle Region) Peptide
BRCA1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all BRCA1 products
- BRCA1 (Breast Cancer 1 (BRCA1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BRCA1 antibody (Catalog #: ARP33338_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BRCA1 (Breast Cancer 1 (BRCA1))
- Synonyms
- BRCAI Peptide, BRCC1 Peptide, BROVCA1 Peptide, IRIS Peptide, PNCA4 Peptide, PPP1R53 Peptide, PSCP Peptide, RNF53 Peptide, iris Peptide, pscp Peptide, brcai Peptide, brcc1 Peptide, rnf53 Peptide, brca1 Peptide, BRCA1 Peptide, LOC100224649 Peptide, BRCA1, DNA repair associated Peptide, breast cancer 1 Peptide, breast cancer 1, early onset Peptide, breast cancer 1 L homeolog Peptide, BRCA1 Peptide, brca1 Peptide, LOC755086 Peptide, Brca1 Peptide, brca1.L Peptide
- Background
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The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified.
Alias Symbols: BRCAI, BRCC1, IRIS, PSCP, RNF53, PNCA4, BROVCA1, PPP1R53
Protein Interaction Partner: ETS2,CREBBP,EP300,MAP3K3,MED1,BRCA1,SMAD2,SMAD3,SMAD4,UBB,ACACA,ATR,BRCA2,CCNA1,CCNB1,CCND1,CDK2,CDK4,CSNK2B,E2F1,E2F4,FANCA,HDAC1,HDAC2,JUN,JUNB,JUND,LMO4,MSH2,MSH6,MYC,NFYA,NMI,NUFIP1,POU2F1,RAD51,RAD51,RB1,RBBP4,RBBP7,RBBP8,SP1,TP53,TP53,ABL1,ACACA,AKT1,AR,ATF1,ATR,AURKA,BAP1,BARD1,BRAP,BRCA1,BRCA2,BRCC3,BRIP1,CASP3,CCNA1,CCNA2,CCNB1,CCND1,CDK1,CDK2,CDK4,CDK7,CHEK2,CLSPN,COBRA1,CREBBP,CSNK2A1,CSNK2B,CSTF1,CTBP1,DCLRE1C,DHX9,E2F1,E2F4,ELK1,EP300,ESR1,FAM175A,FANCA,FANCD2,FHL2,GFI1B,H2AFX,HDAC1,HDAC2,IFI16,JAK1,JAK2,JUN,JUNB,JUND,KPNA2,KPNA6,LMO4,MAP3K3,MDC1,MED1,MED21,MLH1,MNAT1,MYC,NBN,NFKB1,NFYA,NMI,NUFIP1,POLR2A,POLR2K,POU2F1,PPP1CA,PSAP,RAD51,RB1,RBBP4,RBBP7,RBBP8,RELA,RFC1,SMAD2,SMAD3,SMAD4,SMARCA2,SMARCA4,SMC1A,SP1,STAT1,STAT3,STAT5A,TOP2A,TP53,TP53BP1,TRRAP,TUBA4A,TUBB,TUBG1,UBB,UBE2D3,UBE2L3,USF2,VCP,XRCC1,YY1,ZNF350,ABL1,ACACA,AKT1,APLP2,AR,ASM4,ATF1,ATM,ATR,AURKA,BACH1,BARD1,BLM,BRAP,BRCA1,BRCA2,BRCC3,BRD7,BRE,BRIP1,CCNA1,CCNA2,CCNB1,CCND1,CCNE1,CCR4,CDK1,CDK16,CDK2,CDK4,CDK5,CDK8,CDS1,CHEK2,CLSPN,COBRA1,CREB1,CREBBP,CSNK2A1,CSNK2B,CSTF1,CSTF2,CTBP1,CTCFL,DEF1,DHH1,DHX9,DNAJA3,E2F4,ELK4,EP300,ESR1,ETS1,FANCA,FANCD2,FHL2,FLI1,GTF2E1,GTF2F1,GTF2H4,H2AFX,H2AFY,HDAC1,HDAC2,HIST2H2AC,HIST2H3C,HSPA8,Ifi204,JAK1,JAK2,JUN,JUNB,JUND,KIF1B,KPNA2,LMO4,MAP3K3,MAP4K4,MDC1,MED1,MED13,MED17,MED21,MED23,MED24,MLH1,MLP2,MRE11A,MRPL39,MSH2,MSH3,MSH6,MYC,NBN,NCOA2,NCOA3,NFYA,NMI,NPM1,NUFIP1,NUP120,NUP133,NUP153,NUP170,NUP188,NUP2,ORC2L,ORC3L,PEG3,POLR2A,POM34,POU2F1,PPP1CA,PPP1CB,PPP1R3A,PRKDC,RAD50,RAD51,RB1,RBBP4,RBBP7,RBBP8,RBL1,RBL2,RELA,RFC1,RPL31,SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCC2,SMARCD2,SP1,SPT4,SPT5,STAT1,STAT5A,SUB1,TOP2A,TP53,TP53BP1,TUBG1,UBA1,UBC,UBE2D1,UBE2L3,UBE3A,UIMC1,USF2,VCP,WDR48,WNT2B,XIST,ZCCHC8,ZNF350
Protein Size: 1863 - Molecular Weight
- 208 kDa
- Gene ID
- 672
- NCBI Accession
- NM_007294, NP_009225
- UniProt
- P38398
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