Complement Component C4b (C4b) (N-Term) Peptide
C4b
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all C4B (C4b) products
- C4B (C4b) (Complement Component C4b (C4b))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-C4B antibody (Catalog #: ARP41841_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- C4B (C4b) (Complement Component C4b (C4b))
- Synonyms
- C4B1 Peptide, C4B12 Peptide, C4B2 Peptide, C4B3 Peptide, C4B5 Peptide, C4BD Peptide, C4B_2 Peptide, C4F Peptide, CH Peptide, CO4 Peptide, CPAMD3 Peptide, C4 Peptide, C4A2 Peptide, C4A3 Peptide, C4A4 Peptide, C4A6 Peptide, C4AD Peptide, C4S Peptide, CPAMD2 Peptide, RG Peptide, wu:fi14a03 Peptide, C4B Peptide, DKFZP469I0332 Peptide, Slp Peptide, Ss Peptide, C4-2 Peptide, C4l Peptide, complement C4B (Chido blood group) Peptide, complement C4A (Rodgers blood group) Peptide, complement component 4 Peptide, complement C4-B Peptide, complement component 4B (Chido blood group) Peptide, complement component 4A (Rodgers blood group) Peptide, C4B Peptide, C4A Peptide, c4 Peptide, LOC462577 Peptide, C4a Peptide, C4b Peptide
- Background
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C4B is the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: C4A, C4A13, C4A91, C4B1, C4B12, C4B2, C4B3, C4B5, C4F, CH, CO4, CPAMD3, MGC164979
Protein Size: 1744 - Molecular Weight
- 33 kDa
- Gene ID
- 432395
- NCBI Accession
- NM_001002029, NP_001002029
- UniProt
- Q6U2E9
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