Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4) Peptide
CACNB4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CACNB4 products
- CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CACNB4 antibody (Catalog #: ARP34959_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
- Synonyms
- CAB4 Peptide, CACNLB4 Peptide, EA5 Peptide, EIG9 Peptide, EJM Peptide, EJM4 Peptide, EJM6 Peptide, 3110038O15Rik Peptide, Cchb4 Peptide, lethargic Peptide, lh Peptide, CACNB4 Peptide, cacnb4.2 Peptide, calcium voltage-gated channel auxiliary subunit beta 4 Peptide, calcium channel, voltage-dependent, beta 4 subunit Peptide, calcium channel, voltage-dependent, beta 4a subunit Peptide, CACNB4 Peptide, Cacnb4 Peptide, cacnb4.1 Peptide, cacnb4 Peptide, cacnb4a Peptide
- Background
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CACNB4 is a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. CACNB4 plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Alias Symbols: CAB4, CACNLB4, EA5, EJM, EIG9, EJM4, EJM6
Protein Interaction Partner: CACNA1A,MED31,PTN,REM1,TBL3,CACNA1A,MED31,PTN,TBL3
Protein Size: 486 - Molecular Weight
- 55 kDa
- Gene ID
- 785
- NCBI Accession
- NM_001005747, NP_001005747
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