Caspase 1 (CASP1) (Middle Region) Peptide
CASP1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Caspase 1 (CASP1) products
- Caspase 1 (CASP1)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LQTRVLNKEE MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CASP1 Antibody(ARP58983_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Caspase 1 (CASP1)
- Synonyms
- ICE Peptide, IL1BC Peptide, P45 Peptide, Il1bc Peptide, Ice Peptide, CASP1 Peptide, CG5370 Peptide, DCP-1 Peptide, DCP1 Peptide, Dcp1 Peptide, Dmel\\CG5370 Peptide, ccp1 Peptide, dcp-1 Peptide, dcp1 Peptide, l(2)01862 Peptide, l(2)02132 Peptide, caspase 1 Peptide, caspase 1, apoptosis-related cysteine peptidase Peptide, caspase 4, apoptosis-related cysteine peptidase Peptide, Death caspase-1 Peptide, caspase-1 Peptide, caspase Peptide, caspase recruitment domain-containing protein 16 Peptide, caspase 4 Peptide, CASP1 Peptide, Casp1 Peptide, CASP4 Peptide, Dcp-1 Peptide, Caspase1 Peptide, LOC5564196 Peptide, LOC451519 Peptide
- Background
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
Alias Symbols: ICE, IL1BC, P45
Protein Interaction Partner: AR,ATN1,ATXN3,HTT,PSEN1,AR,ATN1,ATXN3,BCAP31,BCL2L1,BID,CARD16,CARD17,CARD8,CASP1,CASP14,CAST,CDK11A,CDK11B,EGFR,HTT,IL18,IL1B,LMNA,MAPT,NEDD4,NFE2L2,NLRC4,NLRP1,NOD1,PAK1,PARK2,PARP1,PLA2G4A,PSEN1,PSEN2,PYCARD,RIPK2,TFAP2A,BCAP31,CARD8,CASP1,CASP10,CASP1
Protein Size: 383 - Molecular Weight
- 10 kDa
- Gene ID
- 834
- NCBI Accession
- NM_001223, NP_001214
- UniProt
- P29466
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