Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Middle Region) Peptide
CASP4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Caspase 4 (CASP4) products
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CASP4 Antibody(ARP58990_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) peptide
CASP4 Reactivity: Human, Cow, Cat, Dog, Mouse Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
- Synonyms
- ICE(rel)II Peptide, ICEREL-II Peptide, ICH-2 Peptide, Mih1/TX Peptide, TX Peptide, Casp11 Peptide, CASP13 Peptide, CASP1 Peptide, CASP4 Peptide, Caspl Peptide, ich-3 Peptide, Casp4 Peptide, caspase 4 Peptide, caspase 4, apoptosis-related cysteine peptidase Peptide, caspase-4 Peptide, CASP4 Peptide, Casp4 Peptide, LOC100731032 Peptide
- Background
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This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Alias Symbols: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Protein Interaction Partner: PSEN1,APAF1,APP,CASP10,CASP14,CASP3,CASP4,DSP,IL18,IL1B,NOD1,PLA2G4A,PSEN1,SERPINB9,APAF1,CASP1,CASP10,CASP14,CASP8,CDK2,CTNNBIP1,EIF2S3,GCN1L1,GSN,HEATR2,IL18,IL1F7,KIAA0776,MSH6,MTHFD1L,MYCBPAP,NOD1,NUP93,PSMB1,SLC25A22,SMC1A,SMC2,SMC3,SRPRB,USP9X,VDAC3
Protein Size: 377 - Molecular Weight
- 10 kDa
- Gene ID
- 837
- NCBI Accession
- NM_001225, NP_001216
- UniProt
- P49662
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