Chimerin (Chimaerin) 2 (CHN2) Peptide
CHN2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CHN2 products
- CHN2 (Chimerin (Chimaerin) 2 (CHN2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHN2 antibody (Catalog #: ARP51862_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CHN2 (Chimerin (Chimaerin) 2 (CHN2))
- Synonyms
- 1700026N20Rik Peptide, 4930557O16Rik Peptide, ARHGAP3 Peptide, Bch Peptide, BCH Peptide, CHN2-3 Peptide, RHOGAP3 Peptide, chimerin 2 Peptide, chimerin 2 L homeolog Peptide, chn2 Peptide, CHN2 Peptide, Chn2 Peptide, chn2.L Peptide
- Background
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CHN2 is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. CHN2 plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: ARHGAP3, BCH, MGC138360, RHOGAP3, CHN2-3
Protein Interaction Partner: BAT3,RAC1,RACGAP1,TGFBR1,AKT1,BAT3
Protein Size: 332 - Molecular Weight
- 38 kDa
- Gene ID
- 1124
- NCBI Accession
- NM_001039936, NP_001035025
- UniProt
- P52757
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