CTDSP2 (CTD (Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2) (Middle Region) Peptide
Reactivity: Human
Host: Synthetic
BP, WB
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- Target
- CTDSP2 (CTD (Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CTDSP2 Antibody(ARP52097_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CTDSP2 (CTD (Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2)
- Target Type
- Peptide
- Background
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CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
Alias Symbols: OS4, PSR2, SCP2
Protein Interaction Partner: AR,POLR2A,SNAI1
Protein Size: 271 - Molecular Weight
- 31 kDa
- Gene ID
- 10106
- NCBI Accession
- NM_005730, NP_005721
- UniProt
- O14595
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