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Dickkopf 2 Homolog (DKK2) (C-Term) Peptide

DKK2 Reactivity: Human, Mouse Host: Synthetic BP, WB
Catalog No. ABIN975818
  • Target See all DKK2 products
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Protein Region
    C-Term
    Origin
    Human, Mouse
    Source
    • 3
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-Dkk4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Synonyms
    DKK-2 Peptide, Dkk4 Peptide, zgc:171574 Peptide, dickkopf WNT signaling pathway inhibitor 2 Peptide, DKK2 Peptide, Dkk2 Peptide, dkk2 Peptide
    Background
    Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

    Alias Symbols: Dkk-4, MGC25705

    Protein Size: 221
    Molecular Weight
    24 kDa
    Gene ID
    234130
    NCBI Accession
    NM_145592, NP_663567
    UniProt
    Q8VEJ3
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