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Early Growth Response 4 (EGR4) Peptide

EGR4 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN976190
  • Target See all EGR4 products
    EGR4 (Early Growth Response 4 (EGR4))
    Origin
    Human
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-EGR4 antibody (Catalog #: ARP38090_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    EGR4 (Early Growth Response 4 (EGR4))
    Synonyms
    EGR4 Peptide, NGFI-C Peptide, NGFIC Peptide, PAT133 Peptide, NGF1-C Peptide, pAT133 Peptide, Egr4l1 Peptide, early growth response 4 Peptide, EGR4 Peptide, Egr4 Peptide
    Background
    The nerve growth factor-induced clone C (NGFI-C/EGR4) gene is a zinc-finger transcription factor that is rapidly induced by nerve growth factor in rat pheochromocytoma PC12 cells and by seizure in brain. NGFI-C/EGR4 is closely related to the previously described early response genes, nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3. These four early response (immediate early) proteins all contain very similar zinc-finger DNA binding domains and five highly homologous subdomains. EGR-4 functionally cooperate with NFAT proteins and induce expression of IL-2 and TNFalpha. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.

    Alias Symbols: NGFIC, NGFI-C, PAT133

    Protein Interaction Partner: NFATC2

    Protein Size: 486
    Molecular Weight
    51 kDa
    Gene ID
    1961
    NCBI Accession
    NM_001965, NP_001956
    UniProt
    Q05215
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