F-Box Protein 31 (FBXO31) (Middle Region) Peptide
FBXO31
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FBXO31 products
- FBXO31 (F-Box Protein 31 (FBXO31))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QGPRESQPSP AQPRAEAPSK GPDGTPGEDG GEPGDAVAAA EQPAQCGQGQ
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FBXO31 Antibody(ARP53775_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FBXO31 (F-Box Protein 31 (FBXO31))
- Synonyms
- 1110003O08Rik Peptide, 2310046N15Rik Peptide, Fbx14 Peptide, Fbxo14 Peptide, FBX14 Peptide, FBXO14 Peptide, Fbx31 Peptide, pp2386 Peptide, RGD1561069 Peptide, fbx14 Peptide, fbx31 Peptide, fbxo14 Peptide, fbxo31 Peptide, F-box protein 31 Peptide, F-box protein 31 S homeolog Peptide, F-box protein 31 L homeolog Peptide, Fbxo31 Peptide, FBXO31 Peptide, fbxo31 Peptide, fbxo31.S Peptide, fbxo31.L Peptide
- Background
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FBXO31 is the component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. FBXO31 specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor.
Alias Symbols: DKFZP434B027, DKFZp434J1815, FBX14, FBXO14, FLJ22477, Fbx31, MGC15419, MGC9527, pp2386
Protein Interaction Partner: CUL1,RBX1,SKP1
Protein Size: 367 - Molecular Weight
- 40 kDa
- Gene ID
- 79791
- NCBI Accession
- NM_024735, NP_079011
- UniProt
- Q5XUX0
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