Frizzled Family Receptor 8 (FZD8) (N-Term) Peptide

Details for Product No. ABIN977174, Supplier: Log in to see
Protein Name
  • FZ-8
  • FZD8
  • cFz-8
  • Fz-8
  • frizzled8
  • xfz8
  • Xfz8
  • frizzled-8
  • hfz8
  • hFZ8
  • fzd8
  • Fz8
  • frizzled family receptor 5
  • frizzled family receptor 8
  • frizzled homolog 8 (Drosophila)
  • FZD5
  • fzd8-b
  • FZD8
  • fzd8
  • Fzd8
  • fzd8-a
Protein Region
N-Term
Origin
Human
3
1
1
1
1
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Blocked Antibody anti-FZD8 antibody (Frizzled Family Receptor 8) (N-Term) (ABIN2776728)
Characteristics This is a synthetic peptide designed for use in combination with anti-FZD8 antibody (Catalog #: ARP41283_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Alias Symbols: FZ-8, hFZ8

Protein Interaction Partner: RYK,WNT1,GOPC,LRP5,LRP6,RYK,WNT1,LRP5,LRP6,WNT1

Protein Size: 694
Molecular Weight 73 kDa
Gene ID 8325
NCBI Accession NM_031866, NP_114072
UniProt Q9H461
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.