Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) Peptide
FZR1
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all FZR1 products
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- Protein Region
- N-Term
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RQIIIQNENT VPCVSEMRRT LTPANSPVSS PSKHGDRFIP SRAGANWSVN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Fzr1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- Synonyms
- CDH1-C Peptide, FYR Peptide, FZR Peptide, CDH1 Peptide, fzr1 Peptide, CDC20C Peptide, FZR2 Peptide, HCDH Peptide, HCDH1 Peptide, AW108046 Peptide, Cdh1 Peptide, Fyr Peptide, zgc:55450 Peptide, fizzy and cell division cycle 20 related 1 Peptide, fizzy/cell division cycle 20 related 1 Peptide, fizzy-related protein homolog Peptide, fizzy/cell division cycle 20 related 1 (Drosophila) Peptide, fizzy/cell division cycle 20 related 1a Peptide, Fzr1 Peptide, CDH1-C Peptide, FZR1 Peptide, LOC100027495 Peptide, LOC100179951 Peptide, fzr1a Peptide
- Background
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Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: AW108046, Cdh1, FZR, FZR2, Fyr, HCDH, HCDH1
Protein Size: 493 - Molecular Weight
- 55 kDa
- Gene ID
- 56371
- NCBI Accession
- NM_019757, NP_062731
- UniProt
- Q9R1K5
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