Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (Middle Region) Peptide
IKBKB
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all IKBKB products
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IKBKB antibody (Catalog #: ARP31988_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
- Synonyms
- ikk-beta Peptide, ikk2 Peptide, ikkb Peptide, ikkbeta Peptide, IKBKB Peptide, IKKB Peptide, CG4201 Peptide, DIK Peptide, DLAK Peptide, DmIKK Peptide, DmIKKBeta Peptide, DmIKKb Peptide, DmIKKbeta Peptide, DmIkkbeta Peptide, Dmel\\CG4201 Peptide, Dmikkb Peptide, Dmikkbeta Peptide, IK Peptide, IKK Peptide, IKK-beta Peptide, IKKb Peptide, IKKbeta Peptide, IRD-5 Peptide, IRD5 Peptide, Ik Peptide, Ikkb Peptide, Ikkbeta Peptide, Ird-5 Peptide, Ird5 Peptide, LRK Peptide, Lak Peptide, anon-89Bd Peptide, dIKK Peptide, dIKK-beta Peptide, dIKKbeta Peptide, dLak Peptide, dmIKKbeta Peptide, ikk Peptide, ird Peptide, ird5/DmIkk[beta] Peptide, IKK2 Peptide, NFKBIKB Peptide, AIM-1 Peptide, AI132552 Peptide, IKK-2 Peptide, IKK[b] Peptide, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog Peptide, inhibitor of nuclear factor kappa B kinase subunit beta Peptide, I-kappaB kinase beta Peptide, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Peptide, inhibitor of kappaB kinase beta Peptide, ikbkb.L Peptide, IKBKB Peptide, ikbkb Peptide, IKKbeta Peptide, Ikbkb Peptide
- Background
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NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-203 AL708460.1 9-211 204-3077 AF080158.1 170-3043 3078-3916 AK023193.1 1980-2818
Alias Symbols: FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Protein Interaction Partner: BIRC3,CDC37,CHUK,CHUK,FOXO3,IKBKAP,IKBKB,IKBKG,IL8,MAP3K14,NFKBIA,NFKBIA,NFKBIA,NFKBIB,PRKCQ,ACVR1,AKT1,CASP8,CDC37,CFLAR,CHUK,CSF2RA,CTNNB1,EIF2AK2,EIF2AK3,FANCA,FOXO3,HSP90AA1,HSP90AB1,IKBKAP,IKBKB,IKBKG,IRS1,KIAA1967,MAP3K11,MAP3K13,MAP3K14,MAP3K3,MAP3K7,NCOA3,NFKB1,NFKB2,NFKBIA,NFKBIB,NR2C2,PEBP1,PPM1B,PRKCB,PRKCQ,PRKCZ,RELA,SRC,STAP2,TANK,TBK1,TGFBR1,TNFAIP3,TNFRSF1A,TRAF2,TRAF3IP2,TRPC4AP,UBB,YWHAB,BTRC,CASP8,CDC37,CHUK,CNTN2,CTNNB1,EIF2AK2,FANCA,IKBKAP,IKBKB,IKBKG,IRAK1,IRS1,MAP3K1,MAP3K11,MAP3K13,MAP3K14,MAP3K7,NCOA3,NFKB1,NFKBIA,NFKBIB,PPM1B,PRDX3,PRKCQ,PRKDC,Pebp1,TNFAIP3,TNFRSF1A,TRAF2,TRAF3IP2,TRPC4AP
Protein Size: 756 - Molecular Weight
- 86 kDa
- Gene ID
- 3551
- NCBI Accession
- NM_001556, NP_001547
- UniProt
- O14920
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