Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (N-Term) Peptide
IKBKG
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all IKBKG products
- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IKBKG antibody (Catalog #: ARP30006_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
- Synonyms
- AMCBX1 Peptide, FIP-3 Peptide, FIP3 Peptide, Fip3p Peptide, IKK-gamma Peptide, IP Peptide, IP1 Peptide, IP2 Peptide, IPD2 Peptide, NEMO Peptide, ZC2HC9 Peptide, 1110037D23Rik Peptide, AI848108 Peptide, AI851264 Peptide, AW124339 Peptide, IKK[g] Peptide, Nemo Peptide, nemo Peptide, fj33c07 Peptide, wu:fj33c07 Peptide, zgc:113492 Peptide, MGC97885 Peptide, IKBKG Peptide, IKBKG_1 Peptide, IKBKG_2 Peptide, CG16910 Peptide, DmIKK-gamma Peptide, DmIKKgamma Peptide, Dmel\\CG16910 Peptide, Dmikkgamma Peptide, IKK Peptide, IKK[[gamma]] Peptide, IKKg Peptide, IKKgamma Peptide, KEY Peptide, Kenny Peptide, Key Peptide, dIKK Peptide, dIKK-gamma Peptide, dmIKKgamma Peptide, inhibitor of nuclear factor kappa B kinase subunit gamma Peptide, inhibitor of kappaB kinase gamma Peptide, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Peptide, inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog Peptide, kenny Peptide, IKBKG Peptide, Ikbkg Peptide, ikbkg Peptide, ikbkg.L Peptide, IKBKG_1 Peptide, key Peptide
- Background
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IKBKG is the regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. IKBKG also considered to be a mediator for TAX activation of NF-kappa-B. IKBKG could be implicated in NF-kappa-B-mediated protection from cytokine toxicity.Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM]. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2120 AF261086.1 2-2121
Alias Symbols: AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO
Protein Interaction Partner: BCL10,CYLD,IKBKB,IKBKG,PRKCQ,TAB3,TANK,TRAF3IP2,TRAF3IP2,UBB,ZFAND5,tax,BCL10,BIRC3,CARD10,CARD11,CARD8,CASP8,CDC37,CHUK,COPS3,CREBBP,CYLD,FADD,GSK3B,HSP90AA1,HSP90AB1,HSPA1A,HSPA4,IKBKB,IKBKG,MAP3K14,NCOA3,NFKB1,NFKB2,NFKBIA,NFKBIB,PPM1B,PRKCQ,RAB11B,RALBP1,RIPK1,RIPK2,RNF11,SRC,TANK,TBK1,TNFAIP3,TNFRSF1A,TNIP2,TRAF3IP2,TRPC4AP,TXLNA,UBB,UBE2D3,ZFAND5,ATG16L1,BCL10,CARD8,CDC37,CHUK,CNTN2,COPS3,HSP90AA2,HSPA1A,IKBKB,IRAK1,MAP3K14,NCOA3,NFKB1,NFKB2,PPM1B,RIPK1,RIPK2,TANK,TBK1,TNFAIP3,TNFRSF1A,TRAF3IP2,TRAF6,TRPC4AP,TUBG1,UBC,ZFAND5
Protein Size: 419 - Molecular Weight
- 48 kDa
- Gene ID
- 8517
- NCBI Accession
- NM_003639, NP_003630
- UniProt
- Q9Y6K9
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