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Interleukin 1, beta (IL1B) Peptide

IL1B Reactivity: Human Host: Synthetic BP, WB, IHC
Catalog No. ABIN978486
  • Target See all IL-1 beta (IL1B) products
    IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
    Origin
    Human
    Source
    • 11
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-IL1B antibody (Catalog #: ARP54324_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
    Synonyms
    IL-1 Peptide, IL1-BETA Peptide, IL1F2 Peptide, IL-1BETA Peptide, IL1beta Peptide, il1-b Peptide, zgc:111873 Peptide, IL-1B Peptide, IL-1beta Peptide, Il-1b Peptide, IL1B Peptide, IL-1 beta Peptide, IL-1b Peptide, interleukin 1 beta Peptide, interleukin 1, beta Peptide, IL1B Peptide, il1b Peptide, Il1b Peptide
    Background
    IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

    Alias Symbols: IL-1, IL1-BETA, IL1F2

    Protein Interaction Partner: A2M,ADRB2,CASP1,CASP4,IL1B,IL1R1,IL1R2,IL1RAP,MMP2,PRTN3,IL1R1,MAPK8IP2,UBE2N,ZNF675

    Protein Size: 153
    Molecular Weight
    17 kDa
    Gene ID
    3553
    NCBI Accession
    NM_000576, NP_000567
    UniProt
    P01584
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