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Janus Kinase 3 (JAK3) (Middle Region) Peptide

JAK3 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN978683
  • Target See all JAK3 products
    JAK3 (Janus Kinase 3 (JAK3))
    Protein Region
    Middle Region
    Origin
    Human
    Source
    • 4
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-JAK3 antibody (Catalog #: ARP54306_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    JAK3 (Janus Kinase 3 (JAK3))
    Synonyms
    JAK-3 Peptide, JAK3_HUMAN Peptide, JAKL Peptide, L-JAK Peptide, LJAK Peptide, fae Peptide, wil Peptide, RATJAK3 Peptide, JAK Peptide, Janus kinase 3 Peptide, JAK3 Peptide, Jak3 Peptide
    Background
    JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

    Alias Symbols: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

    Protein Interaction Partner: JAK3,JAK3,ALK,CD247,CD40,CXCR4,FES,IL2RB,IL2RG,IL4R,IL7R,INPP5D,IRS1,IRS2,JAK1,JAK2,JAK3,KHDRBS1,LCK,PIK3R1,PRMT5,PTK2B,PTPN2,PTPN6,PTPRC,SH2B2,SHB,SOCS1,SOCS3,STAM,STAM2,STAT3,STAT5A,TIAF1,VIL1,ALK,CD247,CD3E,CXCR4,IL2RG,IRS1,LEPR,PRMT5,PTK2B,SHB,STAM,STAM2,STAT5A,STAT5B,TIAF1

    Protein Size: 1124
    Molecular Weight
    125 kDa
    Gene ID
    3718
    NCBI Accession
    NM_000215, NP_000206
    UniProt
    P52333
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