Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2) Peptide
MAP3K2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MAP3K2 products
- MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MAP3K2 antibody (Catalog #: ARP49223_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))
- Synonyms
- Mekk2 Peptide, MEKK2 Peptide, MEKK2B Peptide, 9630061B06Rik Peptide, AI585793 Peptide, Mekk2b Peptide, mitogen activated protein kinase kinase kinase 2 Peptide, mitogen-activated protein kinase kinase kinase 2 Peptide, Map3k2 Peptide, MAP3K2 Peptide
- Background
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MAP3K2 is a component of a protein kinase signal transduction cascade. It regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. It also plays a role in caveolae kiss-and-run dynamics.The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-18 AF111105.1 37-54 19-79 AI760702.1 474-534 80-371 AF111105.1 116-407 372-2650 AB208963.1 313-2591 2651-3557 AK075004.1 2050-2956 3558-3571 BQ423724.1 71-84 3572-3577 W07290.1 11-16 3578-4302 AK074577.1 1-725 4303-4421 BM470563.1 21-139 4422-4424 AK074577.1 845-847 4425-4941 BM470563.1 142-658
Alias Symbols: MEKK2, MEKK2B
Protein Interaction Partner: MAP2K5,MAP2K7,MAP3K2,MAP2K4,MAP2K5,MAP2K7,MAP3K5,MAPK8,NFKBIA,PKN2,SH2D2A,SMURF1,WNK1,YWHAE,YWHAG,YWHAZ,MAP2K4,MAP2K5,MAP2K7,MAPK8,SFN,SH2D2A,XIAP,YWHAE
Protein Size: 619 - Molecular Weight
- 70 kDa
- Gene ID
- 10746
- NCBI Accession
- NM_006609, NP_006600
- UniProt
- Q9Y2U5
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