Mitochondrial Ribosomal Protein S12 (MRPS12) Peptide
MRPS12
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MRPS12 products
- MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MRPS12 antibody (Catalog #: ARP46301_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))
- Synonyms
- MPR-S12 Peptide, MT-RPS12 Peptide, RPMS12 Peptide, RPS12 Peptide, RPSM12 Peptide, AI327385 Peptide, Rpms12 Peptide, rps12 Peptide, CG7925 Peptide, Dmel\\CG7925 Peptide, EG:BACH59J11.1 Peptide, MRP-S12 Peptide, MRPS12 Peptide, S12 Peptide, Tko Peptide, l(1)3Ab Peptide, l(1)tko Peptide, mRpS12 Peptide, mt-rps12 Peptide, MGC64304 Peptide, GB10531 Peptide, mitochondrial ribosomal protein S12 Peptide, technical knockout Peptide, mitochondrial ribosomal protein S12 L homeolog Peptide, 40S ribosomal protein S12, mitochondrial Peptide, putative mitochondrial 37S ribosomal protein MRPS12 Peptide, fragile site, aphidicolin type, common, fra(6)(p22.2) Peptide, MRPS12 Peptide, Mrps12 Peptide, tko Peptide, mrps12.L Peptide, LOC409723 Peptide, mRpS12 Peptide, mrps12 Peptide, CAALFM_C106070WA Peptide, mrpS12 Peptide, FRA6C Peptide
- Background
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Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. MRPS12 is the 28S subunit protein that belongs to the ribosomal protein S12P family. The protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics.Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein.
Alias Symbols: MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12
Protein Interaction Partner: SPINK7,C14orf1,C1orf103,CRMP1,SPINK7,UNC119,C14orf1,C1orf103,CRMP1,SPINK7,UNC119
Protein Size: 138 - Molecular Weight
- 12 kDa
- Gene ID
- 6183
- NCBI Accession
- NM_021107, NP_066930
- UniProt
- O15235
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