Nuclear Transcription Factor, X-Box Binding 1 (NFX1) (N-Term) Peptide
NFX1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NFX1 products
- NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NFX1 antibody (Catalog #: ARP34770_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))
- Synonyms
- NFX1 Peptide, NFX2 Peptide, 1300017N15Rik Peptide, 3000003M19Rik Peptide, NFX.1 Peptide, TEG-42 Peptide, Tex42 Peptide, nuclear transcription factor, X-box binding 1 Peptide, nuclear transcription factor, x-box binding 1 Peptide, NFX1 Peptide, CpipJ_CPIJ011986 Peptide, nfx1 Peptide, Nfx1 Peptide
- Background
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NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Alias Symbols: DKFZp779G2416, MGC20369, NFX2
Protein Interaction Partner: ELAVL4,NUP153,NUP214,NUP62,NUP98
Protein Size: 1024 - Molecular Weight
- 113 kDa
- Gene ID
- 4799
- NCBI Accession
- NM_147133, NP_667344
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