GTPase NRas (NRAS) (Middle Region) Peptide
NRAS
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GTPase NRas (NRAS) products
- GTPase NRas (NRAS)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NRAS Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GTPase NRas (NRAS)
- Synonyms
- NRAS Peptide, AV095280 Peptide, N-ras Peptide, ALPS4 Peptide, NRAS1 Peptide, NS6 Peptide, N-RAS Peptide, fj99a10 Peptide, wu:fj99a10 Peptide, zgc:100761 Peptide, zras-b1 Peptide, H-RAS Peptide, HRAS Peptide, GTPase NRas Peptide, neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog Peptide, NRAS proto-oncogene, GTPase Peptide, neuroblastoma ras oncogene Peptide, neuroblastoma RAS viral oncogene homolog Peptide, Tsp_01117 Peptide, nras.L Peptide, Nras Peptide, NRAS Peptide, nras Peptide
- Background
-
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Alias Symbols: ALPS4, N-ras, NRAS1, NS6
Protein Interaction Partner: RAF1,ACVR1,ARHGAP4,BCL2,PIK3CA,PLCE1,RACGAP1,RAF1,RAP1GDS1,RASGRP2,RASSF5,SHOC2,SMAD4,SMURF2,MLLT4,PIK3CG,PLCE1,RAF1,RAP1GDS1
Protein Size: 189 - Molecular Weight
- 21 kDa
- Gene ID
- 4893
- NCBI Accession
- NM_002524, NP_002515
- UniProt
- P01111
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