Nuclear Respiratory Factor 1 (NRF1) (N-Term) Peptide
NRF1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NRF1 products
- NRF1 (Nuclear Respiratory Factor 1 (NRF1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NRF1 antibody (Catalog #: ARP38542_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NRF1 (Nuclear Respiratory Factor 1 (NRF1))
- Synonyms
- ALPHA-PAL Peptide, C87038 Peptide, D6Ertd415e Peptide, SC:BZ3C13.1 Peptide, SC:bZ3C13.2 Peptide, ube2h Peptide, Nfe2l1_retired Peptide, IBR/F Peptide, NRF1 Peptide, alpha-pal Peptide, nrf-1 Peptide, LOC100220087 Peptide, nuclear respiratory factor 1 Peptide, nuclear respiratory factor 1 S homeolog Peptide, NRF1 Peptide, Nrf1 Peptide, nrf1 Peptide, nrf1.S Peptide
- Background
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NRF1 is a phosphorylated nuclear protein with a bZIP domain. This protein homodimerizes and functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
Alias Symbols: ALPHA-PAL
Protein Interaction Partner: CDK1,MRP63,TFAM,DYNLL1,MAFF,PPARGC1A,PPRC1,DYNLL1,Dynll1,Dynlt1b,MAFF,PPARGC1A,PPRC1
Protein Size: 503 - Molecular Weight
- 53 kDa
- Gene ID
- 4899
- NCBI Accession
- NM_005011, NP_005002
- UniProt
- Q16656
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