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Nuclear RNA Export Factor 3 (NXF3) Peptide

NXF3 Reactivity: Human, Drosophila melanogaster Host: Synthetic BP, WB
Catalog No. ABIN981055
  • Target See all NXF3 products
    NXF3 (Nuclear RNA Export Factor 3 (NXF3))
    Origin
    Human, Drosophila melanogaster
    Source
    • 4
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-NXF3 antibody (Catalog #: ARP40973_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    NXF3 (Nuclear RNA Export Factor 3 (NXF3))
    Synonyms
    NXF3 Peptide, Gm384 Peptide, RGD1564923 Peptide, nuclear RNA export factor 3 Peptide, NXF3 Peptide, LOC523530 Peptide, LOC100060140 Peptide, LOC100060240 Peptide, LOC785244 Peptide, Nxf3 Peptide
    Background
    NXF3 is one member of a family of nuclear RNA export factors. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF3 has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

    Alias Symbols: -

    Protein Interaction Partner: HNRNPUL1,NXT1,NXT2,XPO1,NUP214,NXT1,NXT2,XPO1

    Protein Size: 531
    Molecular Weight
    60 kDa
    Gene ID
    56000
    NCBI Accession
    NM_022052, NP_071335
    UniProt
    Q9H4D5
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