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Platelet Derived Growth Factor Subunit B (PDGFB) (N-Term) Peptide

PDGFB Reactivity: Human Host: Synthetic BP, IHC, WB
Catalog No. ABIN981524
  • Target See all PDGFB products
    PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-PDGFB antibody (Catalog #: ARP58509_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))
    Synonyms
    PDGF-2 Peptide, PDGF2 Peptide, SIS Peptide, SSV Peptide, c-sis Peptide, pdgf2 Peptide, sis Peptide, si:ch211-79m20.1 Peptide, si:dkey-261d11.1 Peptide, PDGF-B Peptide, Sis Peptide, platelet derived growth factor subunit B Peptide, platelet-derived growth factor beta polypeptide Peptide, platelet derived growth factor subunit B S homeolog Peptide, platelet-derived growth factor beta polypeptide a Peptide, platelet derived growth factor, B polypeptide Peptide, PDGFB Peptide, pdgfb.S Peptide, pdgfba Peptide, Pdgfb Peptide
    Background
    PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

    Alias Symbols: FLJ12858, PDGF2, SIS, SSV, c-sis

    Protein Interaction Partner: A2M,ART1,COL1A1,HRAS,HSPG2,LRP1,PDAP1,PDGFB,PDGFRA,PDGFRB,THBS1,HSPG2,LRP1,PDAP1,PDGFB,PDGFRA,SPARC,THBS1

    Protein Size: 241
    Molecular Weight
    27 kDa
    Gene ID
    5155
    NCBI Accession
    NM_002608, NP_002599
    UniProt
    P01127
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