Pim-1 Oncogene (PIM1) (N-Term) Peptide
PIM1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PIM1 products
- PIM1 (Pim-1 Oncogene (PIM1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PIM1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PIM1 (Pim-1 Oncogene (PIM1))
- Synonyms
- PIM Peptide, Pim-1 Peptide, PIM1 Peptide, pim Peptide, pim-1 Peptide, pim3 Peptide, Pim-1 proto-oncogene, serine/threonine kinase Peptide, proviral integration site 1 Peptide, Pim-1 proto-oncogene, serine/threonine kinase L homeolog Peptide, PIM1 Peptide, Pim1 Peptide, pim1 Peptide, pim1.L Peptide
- Background
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The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
Alias Symbols: PIM
Protein Size: 313 - Molecular Weight
- 36 kDa
- Gene ID
- 5292
- NCBI Accession
- NM_001243186, NP_001230115
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