Protein Kinase C, zeta (PRKCZ) Peptide
PRKCZ
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PKC zeta (PRKCZ) products
- PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PRKCZ antibody (Catalog #: ARP42881_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))
- Synonyms
- TPKC Peptide, PKCzeta Peptide, prkcz-A Peptide, pkc-zeta Peptide, PRKCZ Peptide, pkc2 Peptide, PKC-ZETA Peptide, PKC2 Peptide, AI098070 Peptide, C80388 Peptide, Pkcz Peptide, R74924 Peptide, aPKCzeta Peptide, zetaPKC Peptide, 14-3-3-zetaisoform Peptide, r14-3-3 Peptide, pkcz Peptide, si:ch211-150o23.4 Peptide, protein kinase C zeta L homeolog Peptide, protein kinase C zeta Peptide, protein kinase C, zeta Peptide, prkcz.L Peptide, PRKCZ Peptide, prkcz Peptide, Prkcz Peptide
- Background
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Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC.Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PKC2, PKC-ZETA
Protein Interaction Partner: HNRNPA1,MBP,PAWR,PDPK1,PDPK1,PRKCSH,PRKCZ,SQSTM1,ADAP1,ADCY5,AFAP1,AKT1,AKT3,BTK,C1QBP,CASP3,CASP6,CASP7,CASP8,CASP9,CDC42,CHAT,CSNK2B,DAPK3,FADD,FEZ1,FEZ2,FRS2,FYN,GLRX3,GRB14,GRM5,GSK3A,GSK3B,HABP4,HRAS,IKBKB,IL4R,IRAK1,IRS1,IRS4,JAK1,KRT10,MAP2K1,MAP2K5,MAPK1,MAPK3,MBP,NCF1,NCL,NFATC2,NUMB,PARD6A,PARD6B,PARD6G,PAWR,PDLIM7,PDPK1,PEBP1,PPP1R14A,PPP3CA,PRG2,PRKCA,PRKCD,PRKCZ,PSEN1,RAF1,RELA,RHOA,SLC39A1,SQSTM1,SRC,STAT6,TRAF6,WWC1,YWHAB,ADAP1,AKT1,AKT3,C1QBP,CSNK2B,DAPK3,ECT2,FADD,FEZ1,FEZ2,GRB14,IRAK1,KRT10,MAP2K5,NCL,NFATC2,PARD3,PARD6A,PARD6B,PARD6G,PAWR,PDPK1,RAF1,RELA,RPS6KB1,SQSTM1,SRC,TIAM1,TRAF6,WWC1,YWHAB,YWHAG,YWHAH,YWHAQ,YWHAZ
Protein Size: 409 - Molecular Weight
- 45 kDa
- Gene ID
- 5590
- NCBI Accession
- NM_001033581, NP_001028753
- UniProt
- Q05513
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