Patched 2 (PTCH2) Peptide
PTCH2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Patched 2 (PTCH2) products
- Patched 2 (PTCH2)
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTCH2 antibody (Catalog #: ARP45522_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Patched 2 (PTCH2)
- Synonyms
- PTC2 Peptide, ptc2 Peptide, Ptch1 Peptide, ptc-2 Peptide, xptc-2 Peptide, xptch-2 Peptide, patched-2 Peptide, ptch2 Peptide, ptc-1 Peptide, ptc1 Peptide, ptch1 Peptide, patched 2 Peptide, patched 2 S homeolog Peptide, patched 2 L homeolog Peptide, PTCH2 Peptide, Ptch2 Peptide, ptch2.S Peptide, ptch2.L Peptide, ptch2 Peptide
- Background
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PTCH2 is a member of the patched protein family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. The gene encoding PTCH2 is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. This gene encodes a member of the patched gene family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. Alternative transcript variants have been described, but their biological function has not been determined. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10 AF119569.1 1-10 11-534 AY359016.1 3-526 535-2066 AF087651.1 523-2054 2067-2509 AF119569.1 2067-2509 2510-2520 AF087651.1 2498-2508 2521-2700 AF119569.1 2521-2700 2701-3620 AY358555.1 2689-3608 3621-3624 AF087651.1 3609-3612
Alias Symbols: PTC2
Protein Interaction Partner: DHH,IHH,SHH,SMO,SMO
Protein Size: 1203 - Molecular Weight
- 130 kDa
- Gene ID
- 8643
- NCBI Accession
- NM_003738, NP_003729
- UniProt
- Q9Y6C5
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