Protein-tyrosine Phosphatase 1C (PTPN6) (Middle Region) Peptide
PTPN6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SHP1 (PTPN6) products
- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- WEEFESLQKQ EVKNLHQRLE GQRPENKGKN RYKNILPFDH SRVILQGRDS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTPN6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
- Synonyms
- HCPH Peptide, HPTP1C Peptide, PTP-1C Peptide, SH-PTP1 Peptide, SHP-1 Peptide, SHP-1L Peptide, SHP1 Peptide, DRPLA Peptide, Hcph Peptide, Ptp1C Peptide, me Peptide, motheaten Peptide, Ptph6 Peptide, Shp-1 Peptide, fj22f05 Peptide, wu:fj22f05 Peptide, zgc:55501 Peptide, ptpn6 Peptide, protein tyrosine phosphatase, non-receptor type 6 Peptide, protein tyrosine phosphatase, non-receptor type 6 L homeolog Peptide, PTPN6 Peptide, Ptpn6 Peptide, ptpn6 Peptide, ptpn6.L Peptide
- Background
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
Alias Symbols: HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Protein Interaction Partner: CAV1,ABL1,ACTN1,ACTN4,BCR,BLNK,BTLA,C6orf25,CAV1,CBL,CD22,CD247,CD300LF,CD33,CD5,CD72,CD79A,CD79B,CEACAM1,CLEC4A,CSF2RB,CTNNB1,CTNND1,CUZD1,CXCR4,DOK1,EGFR,EPOR,ESR1,FAS,FCGR2B,FLT3,GAB2,GHR,GRB2,HOXA10,IFNAR1,IL2RB,IL4R,IL6ST,INSR,IRS2,IRS4,JAK1,JAK2,JAK
Protein Size: 595 - Molecular Weight
- 65 kDa
- Gene ID
- 5777
- NCBI Accession
- NM_002831, NP_002822
- UniProt
- P29350
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