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Rhotekin (RTKN) (Middle Region) Peptide

RTKN Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN983307
  • Target See all Rhotekin (RTKN) products
    Rhotekin (RTKN)
    Protein Region
    Middle Region
    Origin
    Human
    Source
    • 4
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-RTKN antibody (Catalog #: ARP56211_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    Rhotekin (RTKN)
    Synonyms
    RTKN Peptide, rhotekin Peptide, RTKN Peptide, rtkn Peptide, Rtkn Peptide
    Background
    RTKN mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. RTKN may play a novel role in the organization of septin structures.This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Alias Symbols: -

    Protein Interaction Partner: RHOA,RHOA,RHOA,RHOA,RTN4R,GOPC,RAC2,RHOA,RHOC,SMURF1,TAX1BP3,TGFBR1,RHOA,RHOA

    Protein Size: 563
    Molecular Weight
    63 kDa
    Gene ID
    6242
    NCBI Accession
    NM_001015055, NP_001015055
    UniProt
    Q9BST9
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