Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Middle Region) Peptide
RUNX1T1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all RUNX1T1 products
- RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RUNX1T1 antibody (Catalog #: ARP58127_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
- Synonyms
- MTG8 Peptide, si:ch211-232j17.1 Peptide, wu:fi14b07 Peptide, zgc:154044 Peptide, AML1T1 Peptide, CBFA2T1 Peptide, CDR Peptide, ETO Peptide, ZMYND2 Peptide, Cbfa2t1h Peptide, Cbfa2t1 Peptide, runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Peptide, RUNX1 translocation partner 1 L homeolog Peptide, RUNX1 translocation partner 1 Peptide, runx1t1 Peptide, runx1t1.L Peptide, RUNX1T1 Peptide, Runx1t1 Peptide
- Background
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RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Alias Symbols: AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2
Protein Interaction Partner: CBFA2T2,HDAC1,HDAC3,NCOR1,SIN3A,TCF12,TCF12,TCF3,TCF4,ABI3,ATN1,BCL6,C19orf57,CBFA2T3,GFI1,HDAC1,HDAC3,HDAC8,HSP90AA1,ID1,ID3,KPNA1,KPNB1,NCOR1,NCOR2,NECAB2,PRKAR2A,RUNX1T1,SIN3A,TAF9B,TCF3,TCF4,UBQLN4,WBP11,ZBTB16,ABI3,C19orf57,CBFA2T2,CBFA2T3,CEP170L,GFI1,HDAC1,HDAC2,HDAC3,HDAC8,KPNA1,KPNB1,NCOR1,NCOR2,NECAB2,OTUD4,PRKAR2A,RUNX1T1,SIN3A,TAF9B,THRAP3,VDR,WBP11,ZBTB16
Protein Size: 577 - Molecular Weight
- 64 kDa
- Gene ID
- 862
- NCBI Accession
- NM_004349, NP_004340
- UniProt
- B2R6I9
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